Plasmatic concentrations of thymic stromal lymphopoietin in dengue virus-infected children
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Thymic stromal lymphopoietin (TSLP) is a recently described cytokine involved in the physiopathogenesis of allergic and parasitic diseases. After production by epithelial cells in response to different stimuli like bacterial and viral components, the TSLP modulate the function of dendritic cells to generate a Th2-lymphocyte response. In dengue, an endemic viral febrile disease in Colombia, a predominant Th2-cytokine pattern has been described in children suffering forms severe and potentially lethal dengue. Here, it was determined by ELISA, the plasma concentrations of TSLP in children undergoing the acute and convalescent stage, in comparison to healthy and atopic children's levels as controls groups. Results show no significant differences in plasma concentrations of TSLP between healthy and acute-phase dengue-infected children and just atopic children showed significant higher levels of TSLP. However, a significant decrease in plasmatic TSLP was noted between the acute and convalescent phase of the dengue infection. When comparing the TSLP levels to the number of platelets, a known marker of dengue severity, there was no correlation. These findings support the hypothesis that plasma TSLP could not be directly involved in the pathogenesis of dengue infection in children and other local T lymphocyte polarization and systemic factors should be explored.
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