Anti-retroviral (ARV) drug resistance in patients with second therapeutic failure in an HIV program, Colombia

Resistencia a medicamentos Anti-rretrovirales (ARV) en pacientes con segundo fracaso terapéutico en un programa de VIH, Colombia

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Dagoberto Santofimio Sierra Hospital Universitario de Neiva, Colombia.
Johanna Osorio Pinzón Hospital Universitario de Neiva, Colombia, Colombia.
Diego Fernando Salinas Cortés Hospital Universitario de Neiva, Colombia, Colombia.
Jackeline Barreto Hospital Universitario de Neiva, Colombia.
Jorge Andrés Ramos Hospital Universitario de Neiva, Colombia.
Luis Carlos Álvarez Perdomo Hospital Universitario de Neiva, Colombia.
Carlos Gómez A. Hospital Universitario de Neiva, Colombia.
Abstract

Objective. To make a description of ARV drugs in patients with second therapeutic failure in an HIV Program between January and December, 2011. Materials and methods. Adescriptive, retrospective case series study was conducted. It was made a description of HIV mutations, clinical characteristics and laboratory findings of patients with resistance in second therapeutic failure. Results. 30 patients with second therapeutic failure were identified in the study period. The average time of use of ARV therapy per patient was 77.2 (SD = 56). 12 patients underwent three changes of ARV months shema per therapeutic failure and 2 other patients up to four changes of schema. Most frequent mutations were the primary to Protease inhibitors (M46I, I54V, L101) and to inhibitors of Reverse analog Transcriptase of Nucleoside. (Abacavir, Didanosine and Zidovudine, Stavudine). 

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Author Biographies / See

Dagoberto Santofimio Sierra, Hospital Universitario de Neiva, Colombia.

MD, Epidemiólogo Clínico, Magister VIH SIDA, Hospital Universitario de Neiva, Colombia, Colombia.

Johanna Osorio Pinzón, Hospital Universitario de Neiva, Colombia, Colombia.

MD, Internista Infectólogía, Hospital Universitario de Neiva, Colombia, Colombia.

Diego Fernando Salinas Cortés, Hospital Universitario de Neiva, Colombia, Colombia.

MD, Internista Infectólogía, Hospital Universitario de Neiva, Colombia, Colombia.

Jackeline Barreto, Hospital Universitario de Neiva, Colombia.

MD, Control de Antibióticos, Hospital Universitario de Neiva, Neiva, Colombia.

Jorge Andrés Ramos, Hospital Universitario de Neiva, Colombia.

Enf, Epidemiólogo, Msc (c) Epidemiología Clínica, Hospital Universitario de Neiva, Colombia.

Luis Carlos Álvarez Perdomo, Hospital Universitario de Neiva, Colombia.

MD, Internista, Hospital Universitario de Neiva, Colombia.

Carlos Gómez A., Hospital Universitario de Neiva, Colombia.

MD, Internista, Hospital Universitario de Neiva, Colombia.
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