Progressive disseminated histoplasmosis in a HIV-free patient
Histoplasmosis progresiva diseminada en un paciente sin VIH
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Objective. To report a case of progressive disseminated histoplasmosis in a patient without immunodeficiency, HIV Elisa negative and discussion regarding the clinical presentation and diagnosis. Study design: Clinical case report and literature review. Methods. Medical history, histopathology, paraclinics' report, review of articles published in indexed journals. Results. The patient has 1-month length symptoms: weight loss, hemoptysis, progressive dysphagia, skin lesions and ulcerated mucosa. In biopsies taken, intracellular blastoconidias and yeast were identified in lymph tissues, gastric mucosa and bone marrow. Conclusions: It is a case of progressive histoplamasmosis in HIV-free patients with lung, gastric and lymphatic tissue involvement.
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Histoplasmosis. Editorial. (1942). J Am Med Assoc. 119(3):265-266. http://jama.amaassn.org/content/119/3/265.extract
González A, Múnera M. (2007). Histoplasma capsulatum en microbiología de las infecciones humanas. CIB, 742-750.
Kasuga T, White T, Koenig G, Mcewen J, Restrepo A et al. (2003). Phylogeography of the fungal pathogen Histoplasma capsulatum. Molecular ecology, 12:3383-3401. http://nature.berkeley.edu/taylorlab/papers/kasuga2003a.pdf
Restrepo A. Histoplasmosis. (2003). Fundamentos de medicina enfermedades infecciosas. CIB, 316-326.
Castañeda E. (2004). Histoplasmosis: nuevos datos colombianos. IX Curso Internacional de Enfermedades Infecciosas. X Seminario Integral del Sida. II Seminario de Medicina Psicosomática y Psiquiatría de Enlace. Santiago de Cali, Colombia, marzo 31 a abril 3. http://www.cls.org.co/uploaded_user/pdf2004/28.pdf
Valle A, Moreira L, Almeida-Paes R et al. (2006). Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report. Rev Inst Med trop S. Paulo [online]. 48(2):113-116. http://www.scielo.br/pdf/rimtsp/v48n2/a12v48n2.pdf
Kauffman C. (2007). Histoplasmosis: a Clinical and Laboratory Update. Clin Microbiol Rev 20:115-132. http://cmr.asm.org/cgi/reprint/20/1/115?axtoshow=&hits=10&RESULTFORMAT=&fulltext=histoplasmosis&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT
Vargas M, Estrada M., et al. (2006). Histoplasmosis diseminada. Informe de un caso de autopsia y revisión de la literatura. Revista de la Facultad de Medicina, Núm. 003. http://www.ejournal.unam.mx/rfm/no49-3/RFM49307.pdf
Velázquez G, Rueda Z. (2010). Histoplasmosis en pacientes con SIDA. Un estudio de cohorte en Medellín, Colombia. Infectio, 14(S2):S99-S106. http://www.revistainfectio.org/site/Portals/0/vol_14_s2/4_histoplasmosis_en_sida.pdf
Houssein Y, Ross G, Jan VP, Kellie RJ. (2009). Tracheal and Endobronchial Involvement in Disseminated Histoplasmosis: A Case Report Chest, 136(6):1650-1653; doi:10.1378/chest.09-0236http://chestjournal.chestpubs.org/content/136/6/1650.full.pdf
Bolognia J, Braverman I. Manifestaciones cutáneas de enfermedades internas. Harrison principios de medicina interna 17 edición, 54:332-333.
Pinzón T, Lastra G. (2005). Causas de hemoptisis en el Hospital Universitario de Neiva. Revista colombiana de neumología. Edición, volumen 17.4 http://www.asoneumocito.org/upload/Vol-17-4-4_g.pdf
Tobón A, Agudelo C, Rosero D, Ochoa J, Bedout C, Zuluaga C, Arango M, et al. (2005). Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency syndrome and non-human immunodeficiency virus–infected individuals. Am J Trop Med Hyg, 73:576-582 http://www.ajtmh.org/content/73/3/576.full
Arango M, Castañeda E, Agudelo CI, De Bedout C, Agudelo CA, et al. (2011). Histoplasmosis: results of the Colombian National Survey, 1992-2008. Biomédica. 31(3). http://www.revistabiomedica.org/index.php/biomedica/article/view/348
Muñoz C, Cano L, González A. (2010). Detección e identificación de histoplasma capsulatum por el laboratorio: de los métodos convencionales a las pruebas moleculares. Infectio, 14(S2):S145-S158. http://revistainfectio.org/site/portals/0/ojs/index.php/infectio/article/view/26
J Wheat. (2007). Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the infectious diseases society of America. Clin Infect Dis, 45(7): 807-825. http://www.uphs.upenn. edu/bugdrug/antibiotic_manual/historx. pdf
