Choriocarcinoma metastases to Lung
##plugins.themes.bootstrap3.article.main##
It is a patient with a history of hydatidiform mole that after three years was diagnosed with choriocarcinoma metastasis lung. The patient consulted by amenorrhea and abdominal pain. The medical staff began studies finding uterine mass which took pathological study that reported an following that, the patient started chemotherapeutic treatment with a suitable evolution and complete healing. The choriocarcinoma in a rare entity characterized by the absence of chorionic villi, syncytium and abnormal cytotrophoblast, with hemorrhage and necrosis that invades the myometrium and blood vessels. Its main serological marker is the smoked persistent chorionic gonadotropin. This can metastasize mainly in lung, brain, and liver. Lower mortality is recorded at 15% in patients who underwent early diagnosis and timely treatment. It has been shown to be a highly chemosensitive tumor, and therefore, it has a high response despite the presence of metastasis, but it has a high rate of cure.
Downloads
##plugins.themes.bootstrap3.article.details##
Lurain, J.R., Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol, 2011. 204(1): 11-8 DOI: 10.1016/j.ajog.2010.06.072
Lurain, J.R., Gestational trophoblastic disease I:epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol, 2010. 203(6):531-9 DOI: 10.1016/j.ajog.2010. 06.073
Soper, J.T., et al., Diagnosis and treatment of gestational trophoblastic disease: ACOG Practice Bulletin No. 53. Gynecol Oncol, 2004. 93(3): 575-85 DOI: 10.1016/j.ygyno.2004.05.013
Tse, K.Y., et al., An update on gestational trophoblastic disease. Obstetrics, Gynaecology & Reproductive Medicine, 2012. 22(1): 7-15 DOI: https://doi.org/10.1016/j.ogrm.2011.10.004
Deng, L., et al., Combination chemotherapy for highrisk gestational trophoblastic tumour. Cochrane Database Syst Rev, 2009(2): p. CD005196 DOI: https://doi.org/10.1002/14651858.CD005196.pub3
Sebire, N.J. and M.J. Seckl, Gestational trophoblastic disease: current management of hydatidiform mole. BMJ, 2008. 337: p. a1193 DOI: 10.1136/bmj.a1193
Costa, H.L. and P. Doyle, Influence of oral contraceptives in the development of post-molar trophoblastic neoplasia—a systematic review. Gynecol Oncol, 2006. 100(3):579-85 DOI: 10.1016/j.ygyno.2005.09.031
Berkowitz, R.S. and D.P. Goldstein, Current management of gestational trophoblastic diseases. Gynecol Oncol, 2009. 112(3): p. 654-62 DOI: 10.1016/j.ygyno.2008. 09.005
Lurain, J.R., et al., Prognostic factors in gestational trophoblastic tumors: a proposed new scoring system based on multivariate analysis. Am J Obstet Gynecol, 1991. 164(2): 611-6.
Matsui, H., et al., Early pregnancy outcomes after chemotherapy for gestational trophoblastic tumor. J Reprod Med, 2004. 49(7):531-4
Newlands, E.S., The management of recurrent and drugresistant gestational trophoblastic neoplasia (GTN). Best Pract Res Clin Obstet Gynaecol, 2003. 17(6): 905-23.
Petersen, R.W., et al., The impact of molar pregnancy on psychological symptomatology, sexual function, and quality of life. Gynecol Oncol, 2005. 97(2): 535-42. DOI: 10.1016/j.ygyno.2005.01.015
Soper, J.T., Role of surgery and radiation therapy in the management of gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol, 2003. 17(6): 943-57.
Tse, K.Y. and H.Y. Ngan, Gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol, 2012. 26(3): 357-70 DOI: 10.1016/j.bpobgyn.2011.11.009
Woolas, R.P., et al., Influence of chemotherapy for gestational trophoblastic disease on subsequent pregnancy outcome. Br J Obstet Gynaecol, 1998. 105(9):1032-5.