Linfohistiocitosis hemofagocítica

Hemophagocytic lynfohistocytosis

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Jhon Ferney Cerquera Rojas
Liliana del Pilar Lozano Macías
Doris Martha Cecilia Salgado
Resumen
El síndrome hemofagocítico, considerado como una entidad poco frecuente, de etiología multifactorial, y cuya presentación es la de un cuadro grave y de alta letalidad, ofrece dificultades en la aproximación diagnostica temprana. Se presenta el caso de un niño de 26 meses de edad, con síndrome febril prolongado asociado a pancitopenia y visceromegalias (hepatoesplenomegalia) rápidamente crecientes en el curso de la evolución. Durante la hospitalización requiere varias transfusiones de hemoderivados sin mejoría. Se descartan enfermedades infecciosas como toxoplasmosis, citomegalovirus, SIDA, hepatitis B y sífilis, al igual que etiología linfo y mieloproliferativa. Se usan herramientas de laboratorio que orientan el diagnóstico a linfohistiocitosis hemofagocitica secundaría a infección por Virus Epstein-Barr, y recibe tratamiento con Inmunoglobulina y esteroides con evolución satisfactoria. Es importante considerar dentro de las causas de síndrome febril prolongado, patologías como la linfohistiocitosis hemofagocítica, secundaria a agentes comunes en nuestro medio como el Epstein Barr virus.
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Biografía del autor/a / Ver

Jhon Ferney Cerquera Rojas, Universidad Surcolombiana, Hospital Universitario de Neiva, Neiva, Colombia

Residente de Pediatría.

Liliana del Pilar Lozano Macías, Universidad Surcolombiana, Neiva, Colombia

Pediatra, Hospital Universitario de Neiva. Docente Medicina, Universidad Surcolombiana, Neiva, Colombia.

Doris Martha Cecilia Salgado, Universidad Surcolombiana, Neiva, Colombia.

Director Servicio Infectología, Hospital Universitario de Neiva. Docente Medicina, Universidad Surcolombiana, Neiva, Colombia.
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