Prevalence and risk factors related to bleeding of patients when undergoing warfarina therapy at Hernando Moncaleano Perdomo Hospital in Neiva in 2011

Abstract

This research aims at determining bleeding prevalence as Walfarina use complication and related risk factors in adult patients at Hernando Moncaleano Perdomo University Hospital in Neiva. (HMPUH). It is a retrospective period cross-sectional study from 2011, carried out with 67 patients from HMPUH, showing a INR prolongation (INR>3) and Warfarina intake, overanticoagulation diagnose and/or bleeding presence when taking Warfarina. Data analysis was carried out with epi Info v.7.0. and Microsoft Office Excel 14.0.0. A bleeding prevalence related to anticoagulation was found during 2011. It was of 59.70%, being the highest bleeding (62,50%), the most frequent. Main diagnoses having indication of anticoagulation were: mechanical valve prostheses (31, 34%), venous thromboembolism (29,85%), and auricular fibrillation (16,42%). No relation was found between kind of indication and bleeding presence. 75,12% of patients had drug interaction mainly with Lovastatina (35,82%), Omeprazol (28,36%) and Acetaminophen (25,37%). There were 4 deaths (5, 97%) during the study, 2 (5%) fatal bleeding. Statistically significant factors were adequate control, possible protective factor for bleeding presence and being woman, possible risk factor for showing major bleeding. In conclusion, there is high prevalence of bleeding among anticoagulated patients. This study suggests as possible risk factor (3 times higher) in the presence of major bleeding, belonging to female gender and as possible protective factor, being man and keep adequate control; besides bleeding may take place no matter INR.