Krukenberg tumor: prognosis and treatment

##plugins.themes.bootstrap3.article.main##

Cindy Lorena Beltrán Endo Universidad Surcolombiana
José Blanco Pérez Universidad Surcolombiana
Diego Fernando Bolívar Universidad Sucolombiana
Héctor Adolfo Polanía Universidad Surcolombiana, Neiva, Colombia.
Abstract

Krukenberg tumor is a metastatic mucinous tumor of ovary that represents 1-2% from all tumors of this organ. It has a poor prognosis and rapid evolution. Up to 40% of cases it is unlikely to determine the tumor of origin. 


This is a case of a patient having a mass and abnormal uterine hemorrhage diagnosis. The diagnosis approach was controversial: abdominopelvic Computed Axial Tomography (CAT) suggests that mass is of colonic origin, but colonoscopy is negative; that is why patient's diagnosis is reevaluated through a transvaginal CAT scan that shows an ovary tumor. Subsequently, endoscopy of upper digestive tract using biopsy indicates Borman IV diffuse gastric cancer, having ring cells; due to the results, the patient has a right salpingooophorectomy using biopsy which shows ring cells in ovarian stroma confirming the diagnosis. 


These patients' survival is of 12,1 months without surgical intervention; depending also on the neoplasia primary origin. Gastric cancer as a tumor of origin generates a 13-month mean survival and even decreases in case of an advanced cancer which is in contrast to colon-rectal metastasis which shows a 29,6-month rise in survival. It is recommendable to carry out early detection of gastric cancer using endoscopic techniques given that Krukenberg tumor, up to 76% of primary tumors, represent gastric cancer.

Keywords

Downloads

Download data is not yet available.

##plugins.themes.bootstrap3.article.details##

Author Biographies / See

Cindy Lorena Beltrán Endo, Universidad Surcolombiana

Estudiantes programa de medicina, Facultad de Salud

José Blanco Pérez, Universidad Surcolombiana

Estudiantes programa de medicina, Facultad de Salud

Diego Fernando Bolívar, Universidad Sucolombiana

Estudiantes programa de medicina, Facultad de Salud

Héctor Adolfo Polanía, Universidad Surcolombiana, Neiva, Colombia.

Cirujano Endoscopista, Departamento de Cirugía, Hospital Universitario de Neiva, Profesor Asistente, Departamento de Ciencias Clínicas.
References

Krukenberg, F.E. 1896. Fibrosarcoma ovarii mucocellulare (carcinomatodes). Archiv Für Gynäkologie 50:287-321.

Tavassoli, F.A., Devilee, P. 2003. World Health Organization Classification of tumors. Pathology and genetics of tumors of the breast and female genital organs 193-196.

Seidman, J.D., Kurman, R.J., Ronnett, B.M. 2003. Primary and metastatic mucinous adenocarcinomas in the ovaries. Incidence in routine practice with a new approach to improve intraoperative diagnosis. American Journal of Surgical Pathology 27:485-993.

Yakusshiji, M., Tazaki, T., Nishimura, H. et al. 1987. Krukenberg tumors of the ovary: a clinicopathological analysis of 112 cases. Acta obstetrica et gynaecologica Japonica 39:479-485.

Irving, J.A., Vasques, D.R., McGuinness, T.B. 2006. Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract. International Journal of Gynecologic Pathology 25:147-150.

McCluggage, W., Young, R. 2008. Primary Ovarian Mucinous Tumors With Signet Ring Cells Report of 3 Cases With Discussion of Socalled Primary Krukenberg Tumor. American Journal of Surgical Pathology 1373-1379.

Demopolous, R.I., Touger, L., Dubin, N. 1987. Secondary ovarian carcinoma. A clinical and pathological evaluation. International Journal of Gynecologic Pathology 166-175.

Agha, A. Nicastri. 2006. An In-depth Look at Krukenberg Tumor. Archives of Pathology & Laboratory Medicine 130(11):1725-1730.

R. Jiang, J. Tang. 2009. Surgical treatment for patients with different origins of Krukenberg tumors: Outcomes and prognostic factors. European Journal of Surgical Oncology 92-97.

Petru, E., Pickel, H., Heydarfadai, M. 1992. Nongenital cancers metastatic to the ovary. Gynecologic Oncology 44:83-86.

Cheong, J.H., Hyung, W.J. 2004. Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer. Gynecologic Oncology 94:477-482.

McCormick, C.C., Giuntoli, R.L., Garbner, G.J. et al. 2007. The role of cytoreductive surgery for colon cancer metastatic to the ovary. Gynecologic Oncology 105:791-795.

Most read articles by the same author(s)

OJS System - Metabiblioteca |